One of the main architectural characteristics in the central area of Iran is the relation between life and climatic conditions; e.g., the four-seasonal house which is a typical kind of the central-yard house. As the climate of Isfahan is more pleasant than other desert regions in the central part of Iran, wind towers are replaced with skylights to ventilate the pool area of hoze-khane. So far, several researches have been carried out to study the stack effect characteristics and to review wind tower performance. In this paper, a case study is carried out to investigate the effect of the skylight of Mosaver-al-Molki house on the flow pattern and natural ventilation. The performance of skylight on the internal air flow patterns as an effective tool in improving the natural ventilation is investigated by using the Ansys Fluent software. Other elements which have been discussed in this paper are the vault and the columns. These elements have a distinguished effect on distribution of inlet streams in different parts of the hoze-khane. Analysis of the simulation results were obtained for wind velocities of 2.5 m/s and 8 m/s. The numerical results show that wind speed of 2.5 m/s has better performance than wind speed of 8 m/s in terms of ventilation.