During the COVID-19 outbreak in Iran, self-quarantine was a measure to slow the spread of this infection. We conducted this cross-sectional study to explore the psychological effects of the home environment while people had to stay at home for a long time. For the survey, 536 individuals took part. Collecting data was via an online questionnaire including three sections: (1) Demographic characteristics and general information; (2) Home environment features and (3) Negative psychological experiences (NPE) considered as (a) feeling of sadness and depression; (b) feeling of stress and anxiety; and, (c) experiencing domestic violence during quarantine. For data analysis, first, some descriptive information about the participants was presented; then, we used a logistic regression model, one of the classification algorithms in machine learning methods to investigate the association of home environment features and NPE during self-quarantine. The results indicate the home environment affects NPE differently among men and women. Generally, the individuals who were more satisfied with their house performance during quarantine, and people considered the light quality of their house as appropriate; besides, residents with less noise disturbance issues had a better mood during this period. Conversely, failure in the possibility of indoor exercising and the feeling of being in a crowded house increased the level of NPE.
