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This paper describes experimental and numerical investigations on two specimens of frames composed of steel reinforced concrete beam and angle-steel concrete column under horizontal low cyclic loading. Based on the test results, the relationship curves of the horizontal load-displacement and the failure modes are acquired. Meanwhile the hysteretic behaviors, skeleton curves, stiffness degradation, energy dissipation, residential deformation of the two specimens are studied. Nonlinear structural analysis program OpenSEES is employed to predict the experimental curves. Using the verified numerical model, the influences of slenderness ratio, axial compression ratio, steel ratio of column, cross-section moment resistance of I-shaped steel in beam, ratio of longitudinal rebars of beam and prestressing level on skeleton curves are investigated. The results indicated that the two specimens exhibited the favorable ductility and energy dissipation capacity, and the beam depth could be reduced to improve service function because of the application of the prestress. The ultimate horizontal load decreases with the increase of column slenderness ratio, and firstly increases then decreases with the increase of axial compression ratio. In the meantime, the descent segment of skeleton curve is smooth with the increase of column slenderness ratio, and becomes steeper with the increase of axial compression ratio.