To fully explain hydropower unit operational problems, an optimal multi-objective dynamic scheduling model is presented which seeks to improve the efficiency of reservation regulation management. To reflect the actual hydropower engineering project environment, fuzzy random uncertainty and an integrated consideration of the natural resource constraints, such as load balance, system power balance, generation limits, turbine capacity, water head, discharge capacities, reservoir storage volumes, and water spillages, were included in the model. The aim of this research was to concurrently minimize discharges and maximize economic benefit. Subsequently, a new hybrid dynamic-programming based multi-start multi-objective simulated annealing algorithm was developed to solve the hydro unit operational problem. The proposed model and intelligent algorithm were then applied to the Xiaolongmen Hydraulic and Hydropower Station in China. The computational unit commitment schedule results demonstrated the practicality and efficiency of this optimization method.