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This paper presents the numerical analysis of seismic soil-pile-superstructure interaction in soft clay using free-field soil analysis and beam on Winkler foundation approach. This model is developed to compute the nonlinear response of single piles under seismic loads, based on one-dimensional finite element formulation. The parameters of the proposed model are calibrated by fitting the experimental data of largescale seismic soil-pile-structure tests which were conducted on shaking table in UC Berkeley. A comparative evaluation of single piles shows that the results obtained from the proposed procedure are in good agreement with the experimental results.